The transmission in the LS4 cars I guess was known to fail before 100k, but some folks made it far longer. Reminds me of the 4L60-E and LT1 situation. What I always found surprising was the LS4 cars all had the 4T65-E with some upgrades. That transmission (and the 4T60-E) was based on the old 440-T4, which was used in all the 80s mid- and full-size FWD applications (so, not a lot of power). Technically the LS4 cars used the 4T65E-HD but overall the design is old. The Trailblazer SS with the LS2 and 4L70-E has similar issues (lots of torque management required).
Anyway, what's surprising is that in the 90s with the FWD Northstar platforms, GM used the 4T80-E which was stronger. Similar HP and actually the LS4 makes more torque than any Northstar.
http://en.wikipedia.org/wiki/GM_4T80_transmission
The 4T65E was used in that Buick LaSabre that Ed and I test drove from Joan at work. It had slippage issues off the line due to a defect/failure in the pressure modulation control valve (could have been saved but it's a fair amount of labor - and it probably doesn't slip at all when normal people drive it).
http://en.wikipedia.org/wiki/GM_4T65-E_ ... ion#4T65-E
I will say the transmission in the example I drove felt great.